The US has carried out a "very successful attack" on three nuclear sites on Iran, President Donald Trump has said, while Tehran has warned of "everlasting" consequences.
Bunker buster bombs were dropped on the heavily protected Fordow enrichment plant, which is buried deep under a mountain, as well as sites at Natanz and Isfahan.
The dramatic escalation brings the US into direct involvement in the war between Israel and Iran. Tehran's threat of reprisals raises fears of a wider regional conflict.
Follow latest: US bombers strike three Iranian nuclear sites
Iran's foreign minister Abbas Araghchi warned that the US strikes "will have everlasting consequences", adding that his country "reserves all options" to retaliate.
"The events this morning are outrageous and will have everlasting consequences," Mr Araghchi wrote on X. "Each and every member of the UN must be alarmed over this extremely dangerous, lawless and criminal behaviour.
"In accordance with the UN Charter and its provisions allowing a legitimate response in self-defense, Iran reserves all options to defend its sovereignty, interest, and people."
Iran has requested an emergency meeting of the UN Security Council to "maintain international peace and condemn the US strikes", according to state media.
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Iran has fired a barrage of missiles at Israel in response.
Several explosions have been heard over Tel Aviv with Israeli media saying Iranian missiles have hit northern and central Israel, including in Haifa, Ness Ziona, Rishon LeZion and Tel Aviv.
Airspace in the region is closed, with a British Airways flight from London to Dubai turning back overnight as it reached Saudi airspace. It turned around over safety concerns.
Israeli Prime Minister Benjamin Netanyahu hailed the "bold decision" by Mr Trump, saying it would "change history".
The UK's prime minister called on Iran to "return to the negotiating table" and reach "a diplomatic solution to end this crisis".
"Iran's nuclear programme is a grave threat to international security. Iran can never be allowed to develop a nuclear weapon and the US has taken action to alleviate that threat," said Sir Keir Starmer.
Iran has repeatedly denied that it is seeking a nuclear weapon, and the head of the UN's nuclear watchdog said in June that it has no proof of a "systematic effort to move into a nuclear weapon".
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US Senator Chris Murphy posted on X after the strikes that he and other senators received a classified briefing last week that indicated that Iran did not pose an immediate threat through its nuclear program.
"Iran was not close to building a deliverable nuclear weapon," Senator Murphy said. "The negotiations Israel scuttled with their strikes held the potential for success."
Addressing the nation in the hours after the strikes, Mr Trump said that Iran must now make peace or "we will go after" other targets in Iran.
Commenting on the operation, he said that the three Iranian sites had been "obliterated".
"There will be either peace or there will be tragedy for Iran far greater than we have witnessed over the last eight days," he said.
In a posting on Truth Social earlier, Mr Trump said, "All planes are safely on their way home", and he congratulated "our great American Warriors".
He added: "Fordow is gone."
He also threatened further strikes on Iran unless it doesn't "stop immediately", adding: "Now is the time for peace."
Sky News understands there was no UK involvement in the strikes.
'Fordow is gone'
Among the sites hit was Fordow, a secretive nuclear facility buried around 80 metres below a mountain and one of two key uranium enrichment plants in Iran.
"A full payload of BOMBS was dropped on the primary site, Fordow," Mr Trump said. "Fordow is gone."
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There had been a lot of discussion in recent days about possible American involvement in the Iran-Israel conflict, and much centred around the US possibly being best placed to destroy Fordow.
Meanwhile, Natanz and Isfahan were the other two sites hit in the US attack.
Natanz is the other major uranium enrichment plant in Iran and was believed to have possibly already suffered extensive damage in Israel's strikes earlier this week.
Isfahan features a large nuclear technology centre and enriched uranium is also stored there, diplomats say.
US media reported that six 'bunker buster' bombs were used to strike Fordow.
Mr Trump said no further strikes were planned and that he hoped diplomacy would now take over.
It's not yet known what Iran's response will be - particularly as the government was already struggling to repel Israel.
However a commentator on Iranian state TV said every US citizen or military in the region was now a legitimate target.
(c) Sky News 2025: 'Fordow is gone': US warplanes strike three nuclear sites as Iran warns of 'everlasting' consequences